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This is a significant long-term risk, especially for women with conditions like PCOS where estrogen levels may be continuously elevated without sufficient progesterone to trigger a monthly shed

In rare cases, folate deficiency is associated with megaloblastic anemia and birth defects, especially neural tube defects, in children born to mothers with folate deficiency

The maximum dose in a single day or infusion is usually around 500-1,000 mg in clinical research settings