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In a mouse model of Sjgrens syndrome, pharmacological inhibition of Cyp51a1 with ketoconazole suppressed CD4 T cell activation and proliferation, reduced T cell infiltration in salivary gland lesions, and alleviated disease symptoms [33]

Among these, liraglutide in the LEADER study, semaglutide in the SUSTAIN-6, albiglutide in the Harmony Outcomes, dulaglutide in the REWIND, and efpeglenatide in the AMPLITUDE-O exhibited significant beneficial effects on 3-point major adverse cardiac events (3P-MACE: death from CV disease, non-fatal myocardial infarction, and non-fatal stroke), the primary end point of each study, compared to the placebo group, respectively

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Elevated tumor necrosis factor- levels are responsible for the development of cancer cells and increased mortality