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B(a)P mutagenesis of the p53 gene DNA is mutated by cigarette pollutants in a very deliberate fashion that differs, in general, from the mechanism of mutation by endogenous factors

But what happens to smokers who switch to modified-risk products

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When restricting the analysis to the ten studies carried out on children and adolescents, active smoking was associated with an increased pooled relative risk of 1.40 (95% CI 1.241.59)

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