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In smokers volar forearm skin, we found increased epidermal differentiation, which may represent a compensatory mechanism induced as an adaptive response to environmental toxins such as PAHs present in cigarette smoke, or nicotine, both of which have the ability to stimulate keratinocyte differentiation
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It turned out that smokers who switched to "light" cigarettes tended to engage in "compensatory behavior" that boosted nicotine delivery and moved them closer to their usual dose
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The global war on drugs has been an unmitigated disaster, built as it was on the thesis that demand would end if supply was stamped out
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