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[94] Long-term nicotine exposure upregulates cortical nicotinic receptors, but it also lowers the activity of the nicotinic receptors in the cortical vasodilation region
Research on these factors is contributing to the development of treatment strategies that may help to reduce smoking and in turn the high mortality rates that arise due to the high smoking prevalence in this population
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Similarly, the route of administration (e.g., bong, joint) and the use of other psychoactive substances (e.g., alcohol, MDMA, cocaine, amphetamines, Ketamine, LSD) in the previous year did not significantly elevate risk of CAPS
