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40 Neuroinflammation involves the interplay between immune cells, cytokines, adhesion molecules, and matrix metalloproteinases, resulting in cellular damage that can compromise BBB integrity and cerebral vasculature

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Apart from mentioning the increasing incidents of lung cancer and many of the causes behind it such as dust, exhaust gas from cars, tuberculosis, X-ray and pollutants emitted from factories, Mller's paper pointed out that "the significance of tobacco smoke has been pushed more and more into the foreground"

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On average, women smoke more cigarettes per day than men