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Because there is no cure, patients must balance symptom control against the burden of side effects

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In certain embodiments, any controlled-release otic formulation described herein increases the exposure of an active agent and increases the length of time that the concentration of the active agent is above C min by about 30%, about 40%, about 50%, about 60%, about 70%, about 80%, or about 90% compared to a formulation that is not a controlled-release otic formulation

Science 171 (3971): 579581

[DOI] [PMC free article] [PubMed] [Google Scholar] 23.Vesely B, Song S, SanchezRamos J, Fitz S, Solivan S, R