While redox homeostasis via enhanced glutathione production is commonly associated with the normal physiological role of NRF2, collectively our results suggest that NRF2-dependent cancer cell growth does not require this enhanced glutathione production
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The body can convert GSSG back into the active GSH form using an enzyme called glutathione reductase, provided there are adequate levels of NADPH, a compound integral to many cellular processes, including the antioxidant response
6.2.2 Therapeutic strategies targeting astrocytic ferroptosis Astrocytes, the most abundant glial cells in the central nervous system, play essential roles in supporting neuronal function, regulating antioxidant defense, and maintaining metabolic homeostasis
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