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Early amylin analog development was marked by pramlintide's modest clinical impact (~23% weight loss) and poor adherence due to three-times-daily dosing

Tirzepatide side effects (Phase 3 data) Nausea: 24-33% of participants (dose-dependent) Diarrhea: 18-23% Vomiting: 8-13% Constipation: 11-17% Discontinuation due to adverse events: 4.3-7.1% Serious adverse events: similar to placebo The difference in discontinuation rates is striking

On dosing cycles: The exploratory oral dosing range is 250-1,000 mcg/day, with 500 mcg BID being the most studied protocol

Kisspeptin: controls GnRH neurons and puberty onset

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