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It then binds to intrinsic factor (IF), a glycoprotein secreted by the parietal cells of the gastric mucosa

However, these mainstream therapies face critical limitations including the rapid emergence of drug resistance, FKS1/FKS2 gene mutations reducing -1,3-glucan synthase affinity, Targeted enzyme (Erg11p) modification, overexpression of efflux pumps (CDR1, MDR1), and upregulation of the ergosterol pathway mediate azole resistance (Pristov and Ghannoum, 2019)

Understanding these mechanisms is essential for advancing the treatment and management of DOR [17, 18]

O GHK-Cu est associado ao estmulo da sntese de colgeno e elastina

Appl Microbiol Biotechnol 99:70697078