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Researchers associate nicotine with sleep disruption increased risk of cardiovascular disease obesity poorer cognitive performance mental and emotional impairment This article looks at how nicotine affects sleep quality, how long nicotine can keep a person awake, and factors that can influence how long nicotine remains in the body

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doi: 10.14309/ajg.0000000000000340 51

Diagnosis of IBS by the Rome IV criteria IBS was diagnosed if the patient reported recurrent abdominal pain occurring on average at least one day per week in the last three months that was associated with two or more of the following criteria: abdominal pain related to defecation