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To avoid a potential risk of hypercobalaminemia or possible health risks of high-dose dietary supplements, an annual blood test is recommended, after which targeted substitution can be performed

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Vitamin B12 Injections may be incompatible with some types of drugs, such as warfarin and certain phenothiazines

Preclinical studies demonstrate elevated intracellular NAD+ levels following NNMT inhibition, suggesting a role in metabolic energy regulation