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Long-term use of AChEIs has several shortcomings, including toxic side effects, patient intolerance, and high costs ( There has been much evidence indicating that multitarget drug therapy is more effective than one class of drugs for treating complex diseases such as malignancies (Yang W

The peptides effects on multiple neurotransmitter systems create potential for interactions

Spatial memory is required for finding one's way around a city or a familiar location, for example

Feelings of sleeplessness or overstimulation may occur, discontinue use if feelings persist or worsen