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Although IL-18 knockout mice exhibit reduced pulmonary inflammation and emphysema compared to wild-type mice after cigarette smoke [21, 24], pulmonary inflammation occurred independent of NLRP3/caspase-1 axis after four weeks of cigarette smoke exposure [25]

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Use of Safety Signs for Hazardous Substances Where operations involve potential exposure to hazardous substances or mixtures, Schedule 1 Part 2 (UK/NI) / Schedule 9 Part B (EU/Ireland) - supported by authority guidance (such as HSE Guidance L64 and HSA guidance ) - requires the use of appropriate hazard and warning signs

Research suggests that second-hand smoke can: Increase nasal mucosal inflammation , potentially heightening sensitivity to other allergens such as pollen or pet dander Impair mucociliary clearance , the nose's natural mechanism for trapping and expelling irritants Elevate total and specific IgE levels , which may indicate a heightened allergic response Damage epithelial barrier function , potentially allowing allergens to penetrate nasal tissue more easily Worsen existing congestion and rhinorrhoea (runny nose) in sensitised individuals For those living or working in London, where shared indoor environments from offices to public transport can expose individuals to residual smoke particles (sometimes referred to as "third-hand smoke"), awareness of these effects can be particularly relevant