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Potential Side Effects and Precautions While methylcobalamin injection is generally considered safe, some people might experience minor side effects, such as: Pain or redness at the injection site Mild diarrhea Headache or nausea Rare allergic reactions In patients with kidney issues or those on certain medications, methylcobalamin must be used cautiously

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A large 2026 study found that colon cancer patients with very high B12 levels survived a median of around five years, compared with nearly eleven years for those with normal levels

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