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Corroborating the regulatory role of the GSH antioxidant system in NLRP3 inflammasome activation, recent studies have shown that the assembly of the complex requires the deglutathionylation of ASC by GSH transferase omega 1, under the control of mitochondrial ROS [55]

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Nat Rev Nephrol 13:629646 Chaiyarit S, Thongboonkerd V (2012) Changes in mitochondrial proteome of renal tubular cells induced by calcium oxalate monohydrate crystal adhesion and internalization are related to mitochondrial dysfunction

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