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Several authors from all three studies disclosed ties to biopharmaceutical companies, including Novo Nordisk, which is developing cagrilintide and funded the studies

Conversely, overfeeding increases intra-portal insulin levels that enhances hepatic GH sensitivity to a degree where relatively low GH secretion is sufficient to maintain ambient hepatic IGF-I synthesis and secretion, and normal circulating IGF-I levels ( Figure 1 This review summarizes how changes in hepatic exposure to intra-portal insulin in health and disease states modulates the GH/IGF-I axis

Additionally, some physicians continue to have hesitancy regarding the safety of such medications, which further limits their use

References: [1] Heffernan MA, et al

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