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In addition, TNF- induces the expression of PDK1 via PI3K/Akt-HIF-1 in bFLS 24 and thus might interfere with pyruvate mitochondrial utilization through the TCA cycle 53

Chronic inflammation can lead to a host of health issues, including pain, reduced mobility, and even chronic diseases

Additionally, recent research has delved into the interplay between confinement and other physical cues (e.g., stiffness [90], viscoelasticity [142], and viscosity [161]) in relation to cancer cells, revealing their combined contributions to different cell processes