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Transwells were washed with sterile PBS, then used for various analyses

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Recent mechanistic and epidemiological evidence indicates that conditions such as obesity, type 2 diabetes mellitus, hypertriglyceridemia, coronary heart disease, coronary slow-flow phenomenon, and diabetic peripheral neuropathy share common pathophysiological pathways, most notably insulin resistance, chronic inflammation, lipid metabolism disturbances, and endothelial dysfunction

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