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Its title page bears two hand-written inscriptions of ownership: the first, an Elizabeth Pain on the 13th January 16?3, and the second, nearly a century later, Elias Harry Paine and Mary Paine, their book 1747

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It is perhaps natural that efforts should be made to discredit evidence which suggests a different view. Though Fisher was in the minority, he was not alone in taking this different view. Joseph Berkson, the chief statistician at the Mayo Clinic throughout the 1940s and 50s, was also a prominent skeptic on the smoking-cancer question, as was Charles Cameron, president of the American Cancer Society

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