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Signs of immune cell activation, including increased numbers of white blood cells, monocytes, memory T cells (CD4 + CD45RA + ), activated T cells (e.g., CD7 + CD25+ and CD2 + HLADR + ), and B cells (CD19 + , CD20 + , and CD21 + ), coupled with an increased CD4 + /CD8+ ratio [24,25,26,27], were detected in various study populations of IMDD patients

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Since then, they have been extensively studied for their ability to heal wounds, reduce inflammation, and stimulate collagen synthesis