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Science 296 (5573), 16531655

Similar content being viewed by others Introduction Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of largely unknown etiology leading to death within 34 years after diagnosis 1

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Treatment of a cancer cell line with methylseleninic acid induced expression changes in 951 genes 58

Inhibition of the Xc-system determines the decrease in GSH levels, which indirectly leads to the inactivation of GPX4 and the onset of ferroptosis ( 3+ enters cells with the assistance of transferrin and subsequently converts to Fe 2+ ( 2+ can catalyze the generation of metabolically toxic reactive oxygen species and phospholipid peroxide through the Fenton reaction, leading to cell damage or death (Figure 4)