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Previous research has typically relied on simplified two-product models comparing cigarette use in a Base Case with a Modified Case scenario, limiting the ability to reflect real-world multi-product tobacco use patterns

Ingredients like nicotine, flavourings, and the bases of PG and VG all have potential dental implications, including the risk of staining and enamel damage

Moreover, flavouring agents such as diacetyl have been implicated in chronic respiratory conditions, and emerging studies suggest that chronic e-cigarette exposure may lead to DNA damage, impaired repair mechanisms, and oxidative stresshallmarks of carcinogenesis

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Nicotine is a psychoactive substance that reaches the brain within seconds of inhalation