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territories, and Tribal jurisdictions

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While the half-life of nicotine is about 2 hours, the half-life of cotinine is about 15 hours

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A large cohort study [101] based on self-reported cardiovascular events found no correlation between e-cigarette use and cardiovascular diseases (coronary artery disease, myocardial infarction, and stroke) among individuals who had never smoked before, while the dual use of traditional and e-cigarettes was associated with a 36% higher risk of cardiovascular events compared to exclusive traditional cigarette smokers