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The products have become popular among kids and young adults, in part because of a perception that e-cigarettes are less harmful than cigarettes

Chronic nicotine exposure leads to desensitization of nicotinic receptors, which in turn makes the receptors less responsive to nicotine upon binding, attenuating the cognitive-enhancing effects over time

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Clinical research from the CDC typically uses absorbed nicotine, which puts the figure closer to 1320 packs of cigarettes for an average user