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HFD can metabolic dysfunction-associated steatotic liver disease (MASLD) by increasing the uptake of free fatty acids by hepatocytes, disrupting the balance between de novo synthesis and oxidative degradation of fatty acids, leading to excessive deposition of triglycerides (TG) in hepatocytes

Composed of three amino acidscysteine, glutamine, and glycineGlutathione is essential for numerous physiological functions, including detoxification, immune system support, and combating oxidative stress

The rats were maintained in individual cages, under controlled temperature, humidity and illumination conditions, with water and diet ad libitum for eight weeks

Lipid metabolism in the liver

Jun SY, Sattler SA, Cortez GS, Vermerris W, Sattler SE, Kang C