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In the rodent studies reported to date it has generally been described as tolerated across the dose ranges examined, but comprehensive controlled human safety data do not exist, so conclusions about tolerability in people remain unconfirmed

Nagalla S, Kim S

The effects of melatonin on Cu 2+ -mediated lipid peroxidation (62) and Cu 2+ /H 2 O 2 -induced metal-catalyzed oxidation and protein damage (63) have been found to be protective

This specific biochemical modification creates a highly stable, lipophilic (fat-soluble) shield around the molecule

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