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As of 2023, Altrias OCI margin in the oral tobacco product segment topped 67.4%, while the combustible product segment came in at 59.7%, nearly comparable to that of the smokeless product segment

This confirms not only that mouse models can be relevant to key aspects of human biology [58, 65], but also that the NLRP3 inflammasome is activated by smoke exposure in both mice and humans and may play a role in the inflammatory processes involved in lung tumor promotion [58, 65]