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Institute of Health Metrics and Evaluation

In 1989, Philip Morris entered the fray with a virtually nicotine-free cigarette called Next that it claimed was better than other low-nicotine varieties because its taste was indistinguishable from regular cigarettes

The vapers use them only once

But as the end of the week neared, he had nothing he liked, and he was trying to fend off thoughts of doom

Building on this understanding, we then assemble a validated mathematical and computational model for linkage of existing experiment data, and interrogate the model to reveal novel connections between underlying mechanisms (Figure 1)