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Boxed warnings, also known as black box warnings, are the highest, boldest safety-related warning required by the FDA on opioid medications, which seek to bring consumers awareness to major risks (37)

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[14] It led to the 1954 publication of A Frank Statement , an advertisement designed to cast doubt on the science showing serious health effects from smoking

Circulation 94(1):1925 Rodgman A, Perfetti TA (2013) The chemical components of tobacco and tobacco smoke, 2nd edn Sanchez A et al (2014) Endothelin-1 contributes to endothelial dysfunction and enhanced vasoconstriction through augmented superoxide production in penile arteries from insulin-resistant obese rats: role of ET(A) and ET(B) receptors

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