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patch-clamp studies confirm synaptogenic superiority over BDNF in hippocampal tissue

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Cyanocobalamin formulations contain trace amounts of cyanide and are contraindicated in patients with Leber's hereditary optic neuropathy

Mechanisms include reduction of excitotoxicity and oxidative stress, enhanced neurotrophic factor expression supporting neuronal survival, angiogenesis improving cerebral blood flow, and modulation of dopamine and serotonin systems