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Inhaled smoke delivers nicotine to the brain within 20 seconds, which makes it very addictive comparable to opioids, alcohol and cocaine, Canadas Centre for Addiction and Mental Health says on its website, adding that this rush is a major part of the addictive process

Another concern comes from human trials for Epidiolex, which found that high doses of CBD were associated with signs of liver damage in a small number of study participants

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