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Notably, while the 2D model primarily exhibited oxidative stress-associated signatures (SBS3, SBS5 and SBS18), the organoid system showed a shift toward the smoking-related SBS4 signature

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World Music, Ken Hunt

According to the FDA, tobacco naturally contains several harmful chemicals, including but not limited to: Nicotine Lead Cadmium Nitrates Trace fertilizers The FDA reports that these natural chemicals can be harmful if ingested, smoked or chewed, stating that as the plants grow, the concentration of harmful chemicals builds up and concentrates in the leaves

It can be used for smoking though I certainly feel there are better choices out there