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In the New England Journal of Medicine, Garvey and colleagues [5] report the results of the REDEFINE 1 trial, a 68-week, phase 3a double-blind, placebo-controlled and active-controlled trial evaluating the efficacy and safety of coadministered cagrilintide and semaglutide in adults with obesity [body mass index (BMI) 30 kg/m 2 ] or overweight (BMI 27 kg/m 2 ) with at least one weight-related comorbidity

On average, individuals can expect to see noticeable changes in body composition within a few weeks of starting peptide injections

Metformin has shown promise with small amounts of weight loss, but appears to be more effective at limiting cravings and regulating appetite

For example, women's stomachs may contain less of a key enzyme (alcohol dehydrogenase) needed for the initial breakdown of alcohol

doi: 10.1080/10408398.2016.1247252 155