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Modulating the gut microbiota through targeted interventions, including probiotics, prebiotics, synbiotics, and dietary strategies, offers a promising avenue to restore microbial homeostasis, attenuate systemic inflammation, and improve the clinical management of hypothyroid disorders

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Some LAB and closely related Gram positive organisms are proposed to possess glutathione synthesis and/or utilization machinery

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The results showed that, in the RT group, the phosphorylation level of p-p38, a key component of the MAPK pathway, was markedly increased, while the expression of the adhesion-related proteins -catenin and E-cadherin was significantly decreased (Fig