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Yes, glutathione can help lighten dark spots but the effect is gradual, and the results depend on several factors: Cause of pigmentation (acne, melasma, sun damage, post-inflammatory hyperpigmentation) Skin tone and type Duration of use Method of administration Combination with other treatments For example, in cases of melasma or stubborn acne marks, glutathione is most effective when used alongside other therapies such as chemical peels, lasers, and prescription creams
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PMID: 20225319 Stupnisek M, et al
The pEGCG can lower lactate dehydrogenase release and decrease caspase-3 activity but not decrease caspase-3 activity caused by 6-OHDA