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Studies demonstrate that SG alleviates HFD-induced hepatic inflammation and fibrosis in mice, suppresses ROS generation, enhances SOD, GSH, and CAT activities, and reduces MDA levels in a dose-dependent manner, thereby protecting mitochondrial structural and functional integrity in hepatocytes

Moreover, it has been shown that several mouse strains, e.g

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Based on these observations, two clinical trials were launched on electrical stimulation of the optic nerve in patients suffering from acute optic neuritis