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In a pilot randomized controlled trial, 84 smokers with prediabetes or overweight received either exenatide (a GLP-1 receptor agonist) or a placebo, alongside a nicotine patch and brief counseling

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Furthermore, decreased tonic serotonin levels might alter phasic serotonergic signaling, and could be a factor the meta-analytic finding of slightly (10%) decreased levels of serotonin transporters in brain of depressed individuals compared to age-matched controls (Gryglewski, 2014)