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The elderly (reduced absorption) Pernicious anemia Vegetarians / Vegans (low dietary B12) People taking metformin or acid reflux medications (PPIs) Post-bariatric or gastric-bypass patients Genetic variants in MTRR , MTR , or TCN2 What Has B12 Been Studied For

Figure 1 3.1 Clostridium in IBD IBD is an outcome of a combination of exogenous and endogenous pathogenic factors acting on the intestinal immune system (57, 58) and is broadly categorized as ulcerative colitis (UC) and Crohns disease (CD) (59)