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Because of the severity of the interaction, in published drug databases (i.e UpToDate LexiDrug, Clinical Pharmacology, etc.), the interaction is listed as a Avoid Combination (X) and/or Level 1 (Contraindicated). For this reason, many patients and practitioners avoid the use of methylene blue 9-26

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Direct infusion of nutrients to the bloodstream makes them more bioavailable to depleted cells

However, the capacity of muscle utilization surpasses its normal production