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Since then, the segment has grown to an estimated $28.3 billion industry, with many states passing their own sets of regulations around the products

The mixture is smoked in a similar way to marijuana, usually in rolled cigarettes, but synthetic cannabinoids can also be ingested in other ways, such as swallowing or injections

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First, the bias covariates used, although carefully extracted and evaluated, were based on observable study characteristics and thus may not fully capture unobserved characteristics such as study quality or context, which might be major sources of bias

There is one other problem