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[24] Reiter, A., Hrbert-Loiser, A., Mylocopos, G., Filion, K

Indications: Huntington's Chorea (a hyperkinetic movement disorder) A drug of first choice for this condition Side Effects: Sedation Depression (suicidal tendencies) Parkinsonism symptoms Lacks the hypotensive & GI side effects of reserpine due to its selectivity for central VMAT2 Pharmacokinetics: * undergoes rapid hepatic metabolism involving carbonyl reductase and CYP2D6 to 2 active metabolites -dihydrotetrabenazine (-HTBZ) and -dihydrotetrabenazine (-HTBZ), with eventual renal elimination of metabolites the -HTBZ and -HTBZ metabolites are primarily responsible for the pharmacological & therapeutic effects produced by the parent prodrug Readily crosses the blood brain barrier & depletes cerebral monoamine stores

Nazi officials moved aggressively in an all-out campaign against cigarette smoking in which tobacco was proclaimed an enemy of the people, according to Proctor

A pack that contains 20 cigarettes is user-friendly and people can carry it without any hassle

Pfaff opened a shop in London in 1885