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Protonated nicotine is the ligand of nAChR ( + ] in the e-cigarette aerosol can have a greater impact on cells expressing the nAChRs in the respiratory tract ( Nicotine and Metabolic Syndrome Smoking is a risk factor for insulin resistance in a dose-dependent manner ( Impact of e-Cigarette Exposure on the Generation of Oxidative Stress and Inflammation Atherosclerosis is a chronic inflammatory condition associated with the accumulation of lipids and fibrous elements in the arteries where inflammatory cells are recruited to the arterial walls