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The tobacco might lose its aroma, and the burn may be uneven

The largest part of patients carry small COL5A1 pathogenic variants and the majority of these are null alleles (nonsense, frameshift, out-of-frame splice) leading to functional haploinsufficiency

pack year history = number of packs per day X number of years smoking For example, 1 pack year is equal to smoking 20 cigarettes (1 pack) per day for 1 year, or 40 cigarettes per day for half a year, and so on

Other potential side effects include headaches, fatigue, bruxism, and impaired wound healing

Patients with EDS need to consume the recommended dietary allowance (RDA) of vitamin C, which helps collagen synthesis and enhances wound healing