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In humans, EA intervention (180 mg/day, P.O for 8 weeks) significantly fortified the mean of TAC and the activity of GPX enzymes as well as reduced MDA contents in the serum of type 2 diabetic patients [172]

This enhanced vascularization brings more oxygen and nutrients to damaged tissues, accelerating repair

Activating Nrf2 can directly or indirectly transcriptionally upregulate GPX4 expression and cooperatively induce other antioxidant molecules, forming a comprehensive defense network against lipid peroxidation

Several clinical studies have established beyond any possible doubt that the association is statistically much higher than could be expected by chance ( Table 18-5 )

Proc Natl Acad Sci U S A (1997) 94(16):85638.10.1073/pnas.94.16.8563 40 LinJXMigoneTSTsangMFriedmannMWeatherbeeJAZhouLet alThe role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15