Acute toxicity studies in animals, if extrapolated to humans, implicate a single dose of 10-15 grams necessary to produce significant liver toxicity, although several human case reports have shown toxicity at doses less than 4 grams per day (likely due to having one or more risk factors for sensitivity to toxicity) (Amar 2007)
Multilingual Access and Digital Edition The 2025 Prohibited List, along with the Summary of Modifications and Monitoring Program, is available in English, French, and Spanish
All participants in this study were de-identified using a numbered code
Mood changes mild depressive symptoms and low mood occur in 411% of patients taking Roaccutane, while severe depression is rare at less than 1%
Cyanocobalomin, methylcobalamin and hydroxocobalamin