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However, in the case of a large number of drugs bioavailability differences are negligible and the risks of changing formulation have often been exaggerated
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This capacity of FcRn antagonists to modulate the pharmacokinetics of other IgG-based Ab therapeutics was investigated in a phase I clinical trial (NCT04973566) addressing the effect of nipocalimab on the pharmacokinetics of the IgG Fc-fusion etanercept, which consists of the extracellular domains of tumor necrosis factor-alpha receptor 2 fused to an IgG1 Fc
doi:10.3389/fmolb.2021.799294
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