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As a critical transcriptional transactivator and key effector component of the Hippo pathway, YAP regulates the expression of a diverse array of cell growth-related genes (Gumbiner and Kim, 2014) and has been linked to the pathogenesis of pulmonary hypertension (Bertero et al., 2016), atherosclerosis (Wang et al., 2016), and other vascular diseases

We highlighted that PN is an underestimated problem among PwPD, especially among those receiving LCIG infusion

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It is important to note that these cells only account for about 10% of the total population, which explains why these mutant-specific effects are difficult to discern when observing effects on the cell population as a whole

A cell membrane is composed of a phospholipid bilayer and proteins that function to protect cellular DNA and mediate the exchange of ions and molecules