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2-OH Metabolites CYP1a1 is the enzyme responsible for the metabolism of E1 to 2-OH-E1 and E2 to 2-OH-E2

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Wade, K

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157 While corticosteroids and other immunosuppressive agents exert broad anti-inflammatory effects, direct inhibition of NLRP3 inflammasome activation represents a more specific therapeutic strategy, potentially allowing for more effective suppression of inflammation with reduced off-target effects