Mu P, Feng J, Hu Y, Xiong F, Ma X, Tian L (2022) Botanical drug extracts combined with biomaterial carriers for osteoarthritis cartilage degeneration treatment: a review of 10 years of research
Initially, we regulated with OxyR the expression of the bacterial luciferase gene cluster, luxCDABE , from Photorhabdus luminescens 40 (denoted as oxyR-lux ) as a bioluminescent reporter
Following subcutaneous administration in clinical models: Both components demonstrate prolonged absorption with peak plasma concentrations occurring 24-72 hours post-injection GLP3 exhibits approximately 6-day half-life enabling once-weekly dosing Cagrilintide demonstrates 120-165 hour half-life (5-7 days) suitable for weekly administration Lipid conjugation of both peptides enables albumin binding and extended systemic circulation Distribution patterns show systemic exposure with concentration in metabolically active tissues The fatty diacid modifications on both peptides (C20 for GLP3 , eicosanedioic acid for cagrilintide) serve as albumin-binding moieties that dramatically extend plasma residence time compared to native peptides
For example, GSH-supported formation of Cu + or Fe 2+ can promote Fenton-like reactions that convert H 2 O 2 into highly reactive radicals, thereby damaging cellular macromolecules and promoting multiple forms of cell death 181,182
10.1016/j.ctim.2019.102211 [DOI] [PubMed] [Google Scholar] Moradi Z, Haghjou MM, Zarei M, Colville L, Raza A (2021) Synergy of production of value-added bioplastic, astaxanthin and phycobilin co-products and Direct Green 6 textile dye remediation in Spirulina platensis
